Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.60 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957718 | 0.84 | PRMT5 (0.73) | PRMT5WDR77ALDH1A1KDM4ENPC1 | |
| SCHEMBL19957662 | 0.73 | PRMT5 (0.71) | PRMT5WDR77LMNATSHRMAPK1 | |
| SCHEMBL19957670 | 0.73 | PRMT5 (0.73) | PRMT5WDR77LMNATSHRMAPK1 | |
| SCHEMBL19957640 | 0.72 | PRMT5 (0.71) | PRMT5WDR77ALDH1A1KDM4EHPGD | |
| SCHEMBL19957533 | 0.72 | PRMT5 (0.74) | PRMT5WDR77 | |
| SCHEMBL7237584 | 0.71 | DRD2 (0.62) | PRMT5WDR77ALDH1A1GAAHPGD | |
| SCHEMBL19957688 | 0.71 | PRMT5 (0.71) | PRMT5WDR77LMNATSHRMAPK1 | |
| SCHEMBL19957615 | 0.71 | PRMT5 (0.71) | PRMT5WDR77LMNAMAPK1ALDH1A1 | |
| SCHEMBL13135921 | 0.70 | CYP2D6 (0.63) | PRMT5WDR77GAAHPGDHTT | |
| SCHEMBL15935388 | 0.69 | PRMT5 (1.00) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |