Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.30 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.30 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417610 | 0.75 | NPC1 (0.43) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL13656961 | 0.71 | GPR3 (0.36) | L3MBTL1KDM4EMAPTTSHRHTT | |
| SCHEMBL4067274 | 0.71 | MAPT (0.38) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL8805116 | 0.71 | MAPT (0.38) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL15830162 | 0.70 | NPC1 (0.35) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL15935214 | 0.70 | NPC1 (0.35) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL15070855 | 0.70 | HSP90AA1 (0.35) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL14682709 | 0.68 | HSP90AA1 (0.45) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL8274147 | 0.67 | L3MBTL1 (0.39) | NPC1HSP90AA1L3MBTL1LMNAKDM4E | |
| SCHEMBL12913581 | 0.67 | LMNA (0.42) | LMNAKDM4EMAPTTSHRSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |