Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16417610 | 0.75 | NPC1 (0.43) | MAPTHSP90AA1LMNAMEN1KMT2A | |
| SCHEMBL8805116 | 0.75 | MAPT (0.38) | MAPTHSP90AA1HSP90AB1LMNAMEN1 | |
| SCHEMBL12535507 | 0.71 | LMNA (0.35) | MAPTHSP90AA1LMNAKDM4ENUDT1 | |
| SCHEMBL15935214 | 0.71 | NPC1 (0.35) | MAPTHSP90AA1LMNAKMT2AHTT | |
| SCHEMBL19957787 | 0.71 | NPC1 (0.35) | MAPTHSP90AA1HSP90AB1LMNAHTT | |
| SCHEMBL15830162 | 0.71 | NPC1 (0.35) | MAPTHSP90AA1LMNAKDM4ELIMK1 | |
| SCHEMBL252078 | 0.67 | NCF1 (0.56) | MAPTHSP90AA1HSP90AB1LMNAMEN1 | |
| SCHEMBL29593164 | 0.67 | NCF1 (0.56) | MAPTHSP90AA1HSP90AB1LMNAMEN1 | |
| SCHEMBL4025561 | 0.67 | KDM4E (0.45) | MAPTLMNAKMT2AHTTHIF1A | |
| SCHEMBL15652136 | 0.67 | ADORA2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752624-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2020-08-25 | — | — | US | disclosed |
| US-20180305356-A1 | NOVEL KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2018-10-25 | — | — | US | disclosed |
| US-10000482-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2018-06-19 | — | — | US | disclosed |
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | EFFECTOR THERAPEUTICS, INC. | 2017-05-25 | — | — | US | disclosed |
| US-9637491-B2 | Pyrazolo[4,3-D]pyrimidines as kinase inhibitors | ORIGENIS GMBH (DE) | 2017-05-02 | — | — | US | disclosed |
| EP-1772493-B1 | AZO DYE | FUJIFILM CORP (JP) | 2016-07-20 | — | — | EP | disclosed |
| US-9359308-B2 | Pyrazine kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-20150266882-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-09-24 | — | — | US | disclosed |
| US-20150259340-A1 | NOVEL KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-09-17 | — | — | US | disclosed |
| US-8877760-B2 | Substituted pyrazine-2-carboxamide kinase inhibitors | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-20090056038-A1 | 2-(cyano-),4-((6-methyl-),(7-(cyano-)isothiazolo(4,3-c)pyrid-3-yl)-azo-)phenol; vividcoloring; stability; radiation resistance; shampoo and sweat resistances; friction resistance; heat resistance; alkali resistance; oxidation color dyes; direct dyes; monoazo dyes | KAO CORPORATION (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20090056038-A1 | 2-(cyano-),4-((6-methyl-),(7-(cyano-)isothiazolo(4,3-c)pyrid-3-yl)-azo-)phenol; vividcoloring; stability; radiation resistance; shampoo and sweat resistances; friction resistance; heat resistance; alkali resistance; oxidation color dyes; direct dyes; monoazo dyes | KAO CORPORATION (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20080027221-A1 | Azo Dye | FUJIFILM CORPORATION (JP) | 2008-01-31 | — | — | US | disclosed |
| US-20080027221-A1 | Azo Dye | FUJIFILM CORPORATION (JP) | 2008-01-31 | — | — | US | disclosed |
| EP-1772493-A1 | AZO DYE | Fujifilm Corporation (JP) | 2007-04-11 | — | — | EP | disclosed |
| EP-1381366-A4 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6825201-B2 | ANTIVIRAL ACTIVITY; TREATMENT OF HIV AND AIDS | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-30 | — | — | US | disclosed |
| EP-1381366-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030096825-A1 | Indole, azaindole and related heterocyclic amidopiperazine derivatives | VIIV HEALTHCARE UK (NO. 5) LIMITED (GB) | 2003-05-22 | — | — | US | disclosed |
| WO-2002085301-A2 | INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC AMIDOPIPERAZINE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259340-A1 | NOVEL KINASE INHIBITORS | LRRK2, MYLK2, MYLK | MAPT 470/4885HSP90AA1 1827/4885HSP90AB1 1352/4885 |
| US-20150266882-A1 | PYRAZOLO[4,3-D]PYRIMIDINES AS KINASE INHIBITORS | LRRK2, MYLK2, MYLK | MAPT 501/4885HSP90AA1 2677/4885HSP90AB1 2097/4885 |
| US-20180305356-A1 | NOVEL KINASE INHIBITORS | LRRK2, MYLK2, MYLK | MAPT 470/4885HSP90AA1 1827/4885HSP90AB1 1352/4885 |
| US-20090056038-A1 | 2-(cyano-),4-((6-methyl-),(7-(cyano-)isothiazolo(4,3-c)pyrid-3-yl)-azo-)phenol; vividcoloring; stability; radiation resistance; shampoo and sweat resistances; friction resistance; heat resistance; alkali resistance; oxidation color dyes; direct dyes; monoazo dyes | SCO2, IK, AR | MAPT 4174/4885HSP90AA1 525/4885HSP90AB1 581/4885 |
| US-20080027221-A1 | Azo Dye | IK, ACMSD, ARG1 | MAPT 4796/4885HSP90AA1 4373/4885HSP90AB1 4159/4885 |
| US-10000482-B2 | Kinase inhibitors | LRRK2, MYLK2, MYLK | MAPT 438/4885HSP90AA1 1768/4885HSP90AB1 1288/4885 |
| US-20030096825-A1 | Indole, azaindole and related heterocyclic amidopiperazine derivatives | IDO1, IDO2, INMT | MAPT 2614/4885HSP90AA1 4771/4885HSP90AB1 4669/4885 |
| US-20170145009-A1 | HETEROCYCLIC COMPOUNDS THAT INHIBIT THE KINASE ACTIVITY OF MNK USEFUL FOR TREATING VARIOUS CANCERS | MAP3K9, MAP3K19, MAP3K20 | MAPT 2303/4885HSP90AA1 3799/4885HSP90AB1 3339/4885 |
| US-10752624-B2 | Kinase inhibitors | LRRK2, MYLK2, MYLK | MAPT 438/4885HSP90AA1 1768/4885HSP90AB1 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.