Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 9/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895206 | 0.74 | PDPK1 (0.43) | SMN1; SMN2KMT2AMEN1LMNAMAPT | |
| SCHEMBL23876810 | 0.73 | P2RX7 (0.38) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL19959671 | 0.72 | MAPT (0.43) | TSHRKMT2AMEN1MAPTKDM4E | |
| SCHEMBL23104725 | 0.69 | P2RX7 (0.41) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL16286568 | 0.67 | MMP8 (0.44) | P2RX7SMN1; SMN2HDAC1HDAC6KMT2A | |
| SCHEMBL30441395 | 0.67 | MMP8 (0.44) | P2RX7SMN1; SMN2HDAC1HDAC6KMT2A | |
| SCHEMBL10349460 | 0.67 | TSHR (0.42) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL2437157 | 0.66 | ADRA2A (0.39) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL5041302 | 0.66 | SMN1; SMN2 (0.41) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL5041305 | 0.66 | SMN1; SMN2 (0.41) | P2RX7TSHRSMN1; SMN2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049296-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |