Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19959608 | 0.83 | TNF (0.42) | MAPTALDH1A1GSK3BMEN1KMT2A | |
| SCHEMBL8895206 | 0.79 | PDPK1 (0.43) | MAPTKDM4EALDH1A1SLC6A3MEN1 | |
| SCHEMBL28509173 | 0.76 | MAPT (0.48) | MAPTKDM4EGAAL3MBTL1HTT | |
| SCHEMBL28509175 | 0.76 | MAPT (0.48) | MAPTKDM4EGAAL3MBTL1HTT | |
| SCHEMBL6370632 | 0.76 | FFAR1 (0.50) | MAPTKDM4EGAAL3MBTL1HTT | |
| SCHEMBL23876831 | 0.72 | MAPT (0.40) | MAPTKDM4EGAAL3MBTL1HTT | |
| SCHEMBL19959669 | 0.72 | P2RX7 (0.35) | MAPTKDM4EMEN1KMT2ATSHR | |
| SCHEMBL19939827 | 0.69 | ALDH1A1 (0.57) | MAPTKDM4EGAAL3MBTL1HTT | |
| SCHEMBL18029866 | 0.68 | MAOA (0.50) | MAPTKDM4EGAAL3MBTL1ALDH1A1 | |
| SCHEMBL2649430 | 0.68 | CTBP2 (0.56) | MAPTHTTALDH1A1CYP2A6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049296-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |