Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997413 | 0.90 | MLNR (0.42) | S1PR1NPSR1LMNAMAPTSTAT3 | |
| SCHEMBL1997573 | 0.83 | ALDH1A1 (0.39) | SMN1; SMN2LMNAHTTRECQLALDH1A1 | |
| SCHEMBL1997046 | 0.83 | MEN1 (0.48) | SMN1; SMN2LMNAHTTFFAR1ALDH1A1 | |
| SCHEMBL4134228 | 0.80 | MLNR (0.59) | MLNR | |
| SCHEMBL2002044 | 0.77 | MLNR (0.42) | SMN1; SMN2LMNAALDH1A1RAB9AMLNR | |
| SCHEMBL3559659 | 0.77 | MLNR (0.49) | MLNR | |
| SCHEMBL2858387 | 0.76 | MLNR (0.48) | S1PR1MLNRPTGDR2 | |
| SCHEMBL1995199 | 0.76 | MLNR (0.58) | NPSR1SMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL2002729 | 0.76 | MLNR (0.36) | ALDH1A1MAPTMLNRPTGDR2MEN1 | |
| SCHEMBL377770 | 0.75 | CHRM4 (0.42) | MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |