Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999431 | 0.89 | ALDH1A1 (0.34) | ALDH1A1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL1997413 | 0.86 | MLNR (0.42) | KMT2AMEN1CYP2D6LMNAMAPT | |
| SCHEMBL1996027 | 0.83 | S1PR1 (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL1996929 | 0.83 | KDM4E (0.46) | ALDH1A1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL2766195 | 0.82 | MLNR (0.41) | ALDH1A1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL2856328 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1ATMSMN1; SMN2 | |
| SCHEMBL2002044 | 0.75 | MLNR (0.42) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL2002729 | 0.75 | MLNR (0.36) | ALDH1A1KMT2AMEN1CYP2D6MAPT | |
| SCHEMBL1998238 | 0.74 | MLNR (0.42) | ALDH1A1KMT2AMEN1CYP2D6LMNA | |
| SCHEMBL2003107 | 0.73 | MLNR (0.47) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |