Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 10/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996027 | 0.90 | S1PR1 (0.39) | MLNRSTAT3MEN1LMNAMAPT | |
| SCHEMBL1997573 | 0.86 | ALDH1A1 (0.39) | STAT3MEN1LMNAMAPTKMT2A | |
| SCHEMBL1995199 | 0.85 | MLNR (0.58) | MLNRHTR2CMCHR1MEN1LMNA | |
| SCHEMBL2853570 | 0.79 | MLNR (0.51) | MLNRS1PR1 | |
| SCHEMBL2002044 | 0.78 | MLNR (0.42) | MLNRMEN1LMNAKMT2A | |
| SCHEMBL2002729 | 0.78 | MLNR (0.36) | MLNRMEN1MAPTKMT2APRKAA2 | |
| SCHEMBL4134228 | 0.78 | MLNR (0.59) | MLNRHTR2CMCHR1PRKAA2 | |
| SCHEMBL1997046 | 0.76 | MEN1 (0.48) | MLNRMEN1LMNAMAPTKMT2A | |
| SCHEMBL1999248 | 0.76 | MLNR (0.60) | MLNRHTR2CMCHR1LMNAKMT2A | |
| SCHEMBL1999431 | 0.76 | ALDH1A1 (0.34) | STAT3MEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |