Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | PDE8A | O60658 | 1/20 | 0.37 |
| ▸ | PDE8B | O95263 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960916 | 0.81 | PRMT5 (0.46) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19960853 | 0.76 | FABP5 (0.38) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19953662 | 0.76 | EPHX2 (0.43) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19960684 | 0.75 | HRH3 (0.39) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19960673 | 0.74 | FABP5 (0.43) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19953754 | 0.72 | NAMPT (0.49) | HRH3FABP5 | |
| SCHEMBL19960688 | 0.72 | FABP5 (0.42) | HRH3MAPTFABP5MTNR1AMTNR1B | |
| SCHEMBL19960664 | 0.71 | HDAC8 (0.43) | DRD2HRH3CCR1MTNR1AMTNR1B | |
| SCHEMBL19953513 | 0.71 | GRM7 (0.62) | HRH3BCL2MAPTFABP5MTNR1A | |
| SCHEMBL19953654 | 0.71 | GRM7 (0.62) | HRH3BCL2MAPTFABP5MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |