Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674123 | 0.74 | HTT (0.47) | HTTPTK2MAPTSLC2A1NOS1 | |
| SCHEMBL24553744 | 0.71 | HTT (0.44) | HTTPTK2MAPTSLC2A1NOS1 | |
| SCHEMBL21958684 | 0.71 | HTT (0.44) | HTTPTK2MAPTSLC2A1ALDH1A1 | |
| SCHEMBL22693062 | 0.68 | HTT (0.41) | HTTPTK2MAPTSLC2A1 | |
| SCHEMBL24224504 | 0.68 | HTT (0.41) | HTTPTK2MAPTSLC2A1 | |
| SCHEMBL20272422 | 0.68 | SLC2A1 (0.47) | HTTPTK2MAPTSLC2A1NOS1 | |
| SCHEMBL24121744 | 0.67 | HTT (0.44) | HTTPTK2MAPTSLC2A1ALDH1A1 | |
| SCHEMBL23889355 | 0.67 | HTT (0.44) | HTTPTK2MAPTSLC2A1 | |
| SCHEMBL19661001 | 0.67 | HTT (0.44) | HTTPTK2MAPTSLC2A1 | |
| SCHEMBL21652656 | 0.65 | HTT (0.47) | HTTPTK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049214-A1 | PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER | INCYTE CORPORATION (US) | 2018-03-15 | — | — | WO | disclosed |