Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674123 | 0.79 | HTT (0.47) | HTTPTK2SLC2A1MAPT | |
| SCHEMBL29863669 | 0.76 | NOS1 (0.37) | HTTPTK2SLC2A1 | |
| SCHEMBL23889355 | 0.76 | HTT (0.44) | HTTPTK2SLC2A1MAPT | |
| SCHEMBL24121744 | 0.76 | HTT (0.44) | HTTPTK2SLC2A1MAPT | |
| SCHEMBL8423993 | 0.74 | HTT (0.42) | HTTPTK2SLC2A1MAPT | |
| SCHEMBL22268064 | 0.73 | HTT (0.41) | HTTPTK2SLC2A1MAPT | |
| SCHEMBL19661012 | 0.68 | KDR (0.44) | — | |
| SCHEMBL24348563 | 0.68 | ALDH1A1 (0.39) | HTT | |
| SCHEMBL4839832 | 0.67 | HTT (0.38) | HTTPTK2 | |
| SCHEMBL19964519 | 0.67 | HTT (0.52) | HTTPTK2SLC2A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017205762-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | PHARMACYCLICS LLC (US) | 2017-11-30 | — | — | WO | disclosed |