Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18237978 | 0.76 | HTT (0.37) | HTTPTK2MAPTTRPA1 | |
| SCHEMBL21652560 | 0.72 | HTT (0.46) | HTTPTK2DYRK1AMAPT | |
| SCHEMBL26204680 | 0.69 | HSP90AA1 (0.36) | HTTPTK2MAPTTRPA1 | |
| SCHEMBL21347892 | 0.69 | HTT (0.38) | HTTPTK2 | |
| SCHEMBL2596852 | 0.67 | HTT (0.44) | HTTPTK2DYRK1AMAPT | |
| SCHEMBL12354214 | 0.66 | — | — | |
| SCHEMBL25778111 | 0.65 | HTT (0.47) | HTTPTK2DYRK1AMAPT | |
| SCHEMBL19964519 | 0.65 | HTT (0.52) | HTTPTK2MAPT | |
| SCHEMBL9203151 | 0.65 | ALDH1A1 (0.47) | HTT | |
| SCHEMBL26077501 | 0.65 | METAP2 (0.35) | HTTPTK2TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277024-A1 | NAPHTHYRIDINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2021-09-09 | — | — | US | disclosed |
| WO-2020023551-A1 | NAPHTHYRIDINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277024-A1 | NAPHTHYRIDINE COMPOUNDS AND USES THEREOF | NEK1, NEK11, NEK5 | HTT 3110/4885PTK2 613/4885DYRK1A 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.