Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21157283 | 0.88 | ALOX15 (0.41) | ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL21113144 | 0.87 | RAB9A (0.42) | PRKDCALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL21157331 | 0.87 | EED (0.46) | PRKDCALDH1A1EEDRBBP4SUZ12 | |
| SCHEMBL28886523 | 0.85 | EZH2 (0.42) | PRKDCALDH1A1CNR1EZH2HRH2 | |
| SCHEMBL21251228 | 0.85 | CNR2 (0.38) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21156100 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL21157291 | 0.83 | EED (0.43) | PRKDCALDH1A1EEDRBBP4SUZ12 | |
| SCHEMBL21156531 | 0.83 | ALDH1A1 (0.40) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL21157327 | 0.82 | PRKCZ (0.42) | ALDH1A1L3MBTL1KDM4ETRPV1LMNA | |
| SCHEMBL19964426 | 0.82 | NPC1 (0.41) | ALDH1A1KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524602-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018045971-A1 | PYRIDO FIVE-ELEMENT AROMATIC RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海海和药物研究开发有限公司 | 2018-03-15 | — | — | WO | disclosed |