Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17721301 | 0.81 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1LMNATHRBHSP90B1 | |
| SCHEMBL19968019 | 0.75 | HSP90AA1 (0.40) | HSP90AA1LMNATHRBSMN1; SMN2TRPV4 | |
| SCHEMBL29405584 | 0.75 | HSP90AA1 (0.40) | HSP90AA1LMNATHRBSMN1; SMN2TRPV4 | |
| SCHEMBL411762 | 0.72 | CCR5 (0.46) | — | |
| SCHEMBL27531647 | 0.70 | ALDH1A1 (0.47) | LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL1434641 | 0.69 | HPGD (0.61) | LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL11721563 | 0.69 | SMN1; SMN2 (0.56) | LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL1929985 | 0.68 | HTT (0.70) | POLBALDH1A1 | |
| Ethylene SCHEMBL8517648 | 0.68 | ALDH1A1 (0.45) | LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12272538 | 0.68 | NNMT (0.46) | LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | Scherimg Corporation (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | Scherimg Corporation (US) | 2012-03-15 | — | — | US | disclosed |
| CN-101133046-B | Preparation of ketoamides | SCHERING CORP | 2011-08-03 | — | — | CN | disclosed |
| CN-101133046-B | Preparation of ketoamides | SCHERING CORP | 2011-08-03 | — | — | CN | disclosed |
| JP-2011102328-A | PREPARATION OF KETONE AMIDE | SCHERING CORP | 2011-05-26 | — | — | JP | disclosed |
| US-7759487-B2 | Preparation of ketone amides | SCHERING CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759487-B2 | Preparation of ketone amides | SCHERING CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION | 2010-02-04 | — | — | US | disclosed |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION | 2010-02-04 | — | — | US | disclosed |
| CN-101133046-A | Preparation of ketoamides | SCHERING CORP (US) | 2008-02-27 | — | — | CN | disclosed |
| CN-101133046-A | Preparation of ketoamides | SCHERING CORP (US) | 2008-02-27 | — | — | CN | disclosed |
| EP-1838695-A2 | PREPARATION OF KETONE AMIDES | Shering Corporation (US) | 2007-10-03 | — | — | EP | disclosed |
| EP-1838695-A2 | PREPARATION OF KETONE AMIDES | Shering Corporation (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006074264-A3 | PREPARATION OF KETONE AMIDES | SCHERING CORP (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060247437-A1 | Preparation of ketone amides | SCHERING CORPORATION | 2006-11-02 | — | — | US | disclosed |
| US-20060247437-A1 | Preparation of ketone amides | SCHERING CORPORATION | 2006-11-02 | — | — | US | disclosed |
| WO-2006074264-A2 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION (US) | 2006-07-13 | — | — | WO | disclosed |
| WO-2006074264-A2 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION (US) | 2006-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247437-A1 | Preparation of ketone amides | CCR5, CCR2, ACKR3 | HSP90AA1 4020/4885HSP90AB1 4027/4885LMNA 4444/4885 |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | CCR5, CCR2, ACKR3 | HSP90AA1 4020/4885HSP90AB1 4027/4885LMNA 4444/4885 |
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | CCR5, CCR2, ACKR3 | HSP90AA1 4020/4885HSP90AB1 4027/4885LMNA 4444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.