Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.37 |
| ▸ | BCL2 | P10415 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDE | P14735 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16626641 | 0.88 | POLB (0.38) | POLBMCL1BCL2TDP1BCL2L1 | |
| Hydrochloric Acid SCHEMBL16618961 | 0.88 | POLB (0.38) | POLBMCL1BCL2TDP1BCL2L1 | |
| SCHEMBL19971450 | 0.85 | POLB (0.36) | POLBMCL1BCL2TDP1BCL2L1 | |
| SCHEMBL16619016 | 0.85 | HTR6 (0.39) | POLBMCL1BCL2TDP1BCL2L1 | |
| SCHEMBL16619019 | 0.85 | HTR6 (0.39) | POLBMCL1BCL2TDP1BCL2L1 | |
| SCHEMBL16626642 | 0.82 | HTR6 (0.35) | POLBMCL1BCL2TDP1BCL2L1 | |
| SCHEMBL16626787 | 0.79 | HTR6 (0.40) | HTR6HTTSMN1; SMN2IDEMAPT | |
| SCHEMBL19971346 | 0.79 | IDE (0.41) | HTR6PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL16618771 | 0.78 | HTR6 (0.39) | HTR6HTTSMN1; SMN2IDEMAPT | |
| SCHEMBL19971359 | 0.77 | HTR6 (0.42) | POLBHTR6SMN1; SMN2IDE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | claimed |
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |