SCHEMBL19971392

SCHEMBL19971392

CNC(=O)Oc1cn(S(=O)(=O)c2cccnc2)c2cc(Nc3ccc(C)cc3F)ccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.38
HTT P42858 3/20 0.37
BCHE P06276 2/20 0.36
ACHE P22303 1/20 0.36
NAMPT P43490 3/20 0.35
PPARG P37231 2/20 0.35
PPARD Q03181 2/20 0.35
PPARA Q07869 2/20 0.35
TSHR P16473 1/20 0.34
FBP1 P09467 1/20 0.34
LMNA P02545 2/20 0.34
CLK1 P49759 2/20 0.34
DHODH Q02127 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP17A1 P05093 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19971356 0.87 IDE (0.37) POLBHTTNAMPTTSHRFBP1
SCHEMBL16626073 0.85 HTR6 (0.39) POLBHTTNAMPTFBP1LMNA
Hydrochloric Acid SCHEMBL17959702 0.84 HTR6 (0.39) POLBHTTNAMPTFBP1LMNA
SCHEMBL16619031 0.82 HDAC1 (0.42) POLBHTTNAMPTDHODH
SCHEMBL16626413 0.82 NAMPT (0.37) POLBHTTNAMPTDHODH
SCHEMBL16618840 0.82 POLB (0.37) POLBHTTNAMPTTSHRFBP1
Hydrochloric Acid SCHEMBL16619306 0.81 NAMPT (0.37) POLBHTTNAMPTDHODH
SCHEMBL16619211 0.80 TNFSF11 (0.38) POLBHTTNAMPTTSHRDHODH
SCHEMBL16626071 0.79 POLB (0.36) POLBHTTNAMPTFBP1LMNA
SCHEMBL19971364 0.79 HSD17B10 (0.39) TSHRCHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP claimed
EP-3052484-B1 SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME DAE WOONG PHARMA (KR) 2018-03-21 EP disclosed