Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24156661 | 0.87 | ENPP2 (0.35) | ENPP2LMNASMN1; SMN2GLP1RFYN | |
| SCHEMBL6912864 | 0.75 | LMNA (0.32) | ENPP2LMNASMN1; SMN2GLP1R | |
| SCHEMBL10949551 | 0.75 | ALOX15 (0.46) | LMNASMN1; SMN2FYNCA5AALDH1A1 | |
| SCHEMBL1162430 | 0.73 | GLP1R (0.34) | LMNASMN1; SMN2GLP1R | |
| Hydrochloric Acid SCHEMBL10573659 | 0.73 | ALOX15 (0.45) | LMNASMN1; SMN2FYNCA5AALDH1A1 | |
| SCHEMBL9626200 | 0.72 | LMNA (0.52) | LMNASMN1; SMN2GLP1RALDH1A1MEN1 | |
| SCHEMBL10825036 | 0.71 | LMNA (0.33) | LMNASMN1; SMN2GLP1R | |
| SCHEMBL10825037 | 0.71 | LMNA (0.33) | LMNASMN1; SMN2GLP1R | |
| SCHEMBL11020040 | 0.70 | LMNA (0.33) | LMNASMN1; SMN2BACE1ALDH1A1MEN1 | |
| SCHEMBL24773615 | 0.70 | HSP90AA1 (0.43) | LMNASMN1; SMN2GLP1RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512846-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |