Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 2/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | VHL | P40337 | 1/20 | 0.30 |
| ▸ | ELOC | Q15369 | 1/20 | 0.30 |
| ▸ | ELOB | Q15370 | 1/20 | 0.30 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21189396 | 0.85 | ALDH1A1 (0.36) | NOTUMVHLELOCELOBCES2 | |
| SCHEMBL14053008 | 0.80 | VHL (0.37) | NOTUMVHLELOCELOB | |
| SCHEMBL28195045 | 0.67 | PARP1 (0.50) | PARP1 | |
| SCHEMBL28914080 | 0.67 | ALDH1A1 (0.31) | CES2 | |
| SCHEMBL7840446 | 0.66 | BRD4 (0.34) | VHLELOCELOB | |
| SCHEMBL20511956 | 0.65 | HTR1A (0.47) | DGAT1HTR1ANPC1RAB9APARP1 | |
| SCHEMBL8136278 | 0.65 | KDM4E (0.34) | NOTUM | |
| SCHEMBL10050691 | 0.63 | AURKA (0.37) | MAP2K1DYRK1AVHLELOCELOB | |
| SCHEMBL9404990 | 0.63 | THRB (0.39) | CSNK1A1DYRK1AVHLELOCELOB | |
| SCHEMBL21465508 | 0.62 | CYP1A2 (0.35) | NOTUMPARP1MAP2K1MAP2K2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018052967-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2018-03-22 | — | — | WO | disclosed |