Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841595 | 0.85 | KDM4E (0.36) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL8128418 | 0.83 | KDM4E (0.33) | KDM4EALDH1A1HPGDHSD17B10NOTUM | |
| SCHEMBL8549364 | 0.83 | ALDH1A1 (0.37) | KDM4EMAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8135089 | 0.74 | RAB9A (0.34) | ALDH1A1 | |
| SCHEMBL8405207 | 0.73 | KDM4E (0.38) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL7843121 | 0.70 | TSHR (0.39) | KDM4EMAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL7997428 | 0.69 | KDM4E (0.38) | KDM4EMAPK1ALDH1A1MEN1KMT2A | |
| SCHEMBL14053008 | 0.68 | VHL (0.37) | KDM4EHSD17B10NOTUMHTT | |
| SCHEMBL7841597 | 0.68 | KDM4E (0.33) | KDM4EALDH1A1PTK2 | |
| SCHEMBL8317930 | 0.65 | ALDH1A1 (0.34) | KDM4EALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159904-A | Pyrazole derivatives | IDEMITSU KOSAN CO., LTD. (JP) | 2000-12-12 | — | — | US | disclosed |
| EP-0970956-A1 | PYRAZOLE DERIVATIVES | IDEMITSU KOSAN COMPANY LIMITED (JP) | 2000-01-12 | — | — | EP | disclosed |