Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20224820 | 0.89 | MAPT (0.54) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL3388058 | 0.83 | MAPT (0.48) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL13460189 | 0.82 | MAPT (0.48) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL17848670 | 0.79 | MAPT (0.50) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL26817055 | 0.76 | MAPT (0.54) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL5162285 | 0.76 | MAPT (0.48) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL5162281 | 0.76 | MAPT (0.48) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL4058639 | 0.76 | MAPT (0.48) | MAPTDRD2DRD3KDM4ERXFP1 | |
| SCHEMBL12859678 | 0.76 | PARP1 (0.40) | MAPTKDM4ESMN1; SMN2ADORA2BALDH1A1 | |
| SCHEMBL1130229 | 0.76 | PKM (0.46) | MAPTDRD2DRD3POLBADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763522-B1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2013-03-20 | — | — | EP | disclosed |
| US-8334289-B2 | Pyridin-2-one compounds and their use as modulators of the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2012-12-18 | — | — | US | disclosed |
| US-20110245266-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-10-06 | — | — | US | disclosed |
| US-7960386-B2 | 1-(4-{4-[2-tert-Butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl}butyl)-4-methylpyridin-2(1H)-one; treatment of schizophrenia and/or depression | ABBOTT GMBH & CO. KG (DE) | 2011-06-14 | — | — | US | disclosed |
| US-20080261992-A1 | Pyridin-2-One Compounds and Their Use as Modulators of the Dopamine D3 Receptor | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-10-23 | — | — | US | disclosed |
| EP-1763522-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2005118571-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245266-A1 | PYRIDIN-2-ONE COMPOUNDS AND THEIR USE AS MODULATORS OF THE DOPAMINE D3 RECEPTOR | DRD3, DRD2, PTGDR | MAPT 774/4885DRD2 2/4885DRD3 1/4885 |
| US-20080261992-A1 | Pyridin-2-One Compounds and Their Use as Modulators of the Dopamine D3 Receptor | DRD3, DRD2, MTNR1A | MAPT 726/4885DRD2 2/4885DRD3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.