Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3550137 | 0.86 | FFAR1 (0.53) | IDH1P4HTMLMNAGAAHPGD | |
| SCHEMBL13550298 | 0.83 | IDH1 (0.47) | IDH1MAPTRAB9ASMN1; SMN2P4HTM | |
| SCHEMBL3517268 | 0.83 | LMNA (0.49) | IDH1ALDH1A1P4HTMLMNAGAA | |
| SCHEMBL13140162 | 0.82 | IDH1 (0.47) | IDH1NPC1ALDH1A1MAPTPKM | |
| Hydrochloric Acid SCHEMBL19974577 | 0.81 | MAOB (0.47) | IDH1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL23296263 | 0.78 | PPARG (0.47) | NPC1ALDH1A1MAPTPKMRAB9A | |
| SCHEMBL23296264 | 0.78 | PPARG (0.47) | NPC1ALDH1A1MAPTPKMRAB9A | |
| SCHEMBL20425199 | 0.76 | NR4A1 (0.53) | LMNAALOX5ACACBMAOBFFAR1 | |
| SCHEMBL25922304 | 0.74 | SIGMAR1 (0.46) | IDH1LMNAMAOBL3MBTL1 | |
| SCHEMBL19982217 | 0.73 | LTA4H (0.51) | IDH1MAPTRAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |