Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19976765 | 0.89 | NTRK1 (0.41) | HDAC6JAK2MAPK8GSK3BPLK4 | |
| SCHEMBL19976757 | 0.87 | HDAC6 (0.39) | HDAC6MAPK10MAPK8GSK3BPLK4 | |
| SCHEMBL19976801 | 0.87 | TRPA1 (0.37) | HDAC6JAK2MAPK8GSK3BPLK4 | |
| SCHEMBL19976726 | 0.87 | ABL1 (0.41) | HDAC6JAK2MAPK10MAPK8GSK3B | |
| SCHEMBL19976736 | 0.87 | MAP2K4 (0.44) | HDAC6JAK2MAPK10MAPK8GSK3B | |
| SCHEMBL19976725 | 0.87 | GSK3B (0.52) | HDAC6MAPK10MAPK8GSK3BDYRK1A | |
| SCHEMBL19976929 | 0.86 | RIPK1 (0.37) | HDAC6JAK2DYRK1AAURKBMAPK1 | |
| SCHEMBL19976804 | 0.84 | TRPA1 (0.37) | HDAC6JAK2MAPK8GSK3BPLK4 | |
| SCHEMBL19976846 | 0.83 | KDM4E (0.42) | HDAC6MAPK10MAPK8GSK3BPLK4 | |
| SCHEMBL19976802 | 0.82 | KDR (0.36) | JAK2CDK2FLT4DYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920012-B2 | Indazole guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-20 | — | — | US | disclosed |