Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23766356 | 0.94 | APLNR (0.39) | APLNRPIK3CGESR1CYP19A1ESR2 | |
| SCHEMBL9740781 | 0.80 | ESR1 (0.41) | APLNRPIK3CGESR1CYP19A1ESR2 | |
| SCHEMBL8161406 | 0.80 | APLNR (0.56) | APLNRMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL11261059 | 0.79 | POLB (0.56) | MTNR1AMTNR1BPOLBMEN1KMT2A | |
| SCHEMBL21157880 | 0.79 | CHRM2 (0.40) | APLNRMTNR1AMTNR1B | |
| SCHEMBL10044940 | 0.78 | SLC6A4 (0.53) | PIK3CGMTNR1AMTNR1B | |
| SCHEMBL19776579 | 0.77 | APLNR (0.46) | APLNRPOLBKMT2A | |
| SCHEMBL14255245 | 0.77 | MTNR1A (0.40) | ESR1CYP19A1ESR2MTNR1AMTNR1B | |
| SCHEMBL22710291 | 0.76 | APLNR (0.38) | APLNRPIK3CGMTNR1AMTNR1BPOLB | |
| SCHEMBL19980286 | 0.76 | APLNR (0.38) | APLNRPIK3CGMTNR1AMTNR1BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |