Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044940 | 0.81 | SLC6A4 (0.53) | MTNR1AMTNR1BPIK3CGHTR2ASLC6A4 | |
| SCHEMBL19980124 | 0.80 | APLNR (0.41) | ESR1CYP19A1ESR2APLNRMTNR1A | |
| SCHEMBL11261059 | 0.80 | POLB (0.56) | MTNR1AMTNR1BPOLB | |
| SCHEMBL23766356 | 0.78 | APLNR (0.39) | ESR1CYP19A1ESR2APLNRMTNR1A | |
| SCHEMBL19776579 | 0.78 | APLNR (0.46) | APLNRPOLB | |
| SCHEMBL23671916 | 0.76 | APLNR (0.44) | APLNRHTR2ASLC6A4KCNH2POLB | |
| SCHEMBL9230444 | 0.76 | APLNR (0.44) | APLNRPIK3CGPOLB | |
| SCHEMBL19295490 | 0.75 | SLC6A4 (0.43) | ESR1CYP19A1ESR2MTNR1AMTNR1B | |
| SCHEMBL18944523 | 0.72 | MTNR1A (0.42) | MTNR1AMTNR1BADRA1ATAAR1 | |
| SCHEMBL22710291 | 0.71 | APLNR (0.38) | APLNRMTNR1AMTNR1BPIK3CGHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |