Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344664 | 0.84 | ADH1B (0.46) | ALDH1A1RAB9AMAPTKDM4EHPGD | |
| SCHEMBL21156962 | 0.84 | ALDH1A1 (0.46) | ALDH1A1RAB9AMAPTGLAKDM4E | |
| SCHEMBL21156950 | 0.71 | ALDH1A1 (0.46) | ALDH1A1RAB9AMAPTGLAKDM4E | |
| SCHEMBL24247846 | 0.70 | ALDH1A1 (0.45) | ALDH1A1RAB9AMAPTGLAKDM4E | |
| SCHEMBL17261148 | 0.70 | PLA2G1B (0.47) | ALDH1A1RAB9AMAPTGLAHPGD | |
| SCHEMBL7950040 | 0.68 | RAB9A (0.60) | ALDH1A1RAB9AHPGDLMNAKMT2A | |
| SCHEMBL689542 | 0.68 | CYP2C19 (0.66) | ALDH1A1RAB9AHPGDLMNAKMT2A | |
| SCHEMBL7449229 | 0.67 | ADH1B (0.52) | ALDH1A1RAB9AMAPTHPGDLMNA | |
| SCHEMBL7449222 | 0.67 | ADH1B (0.52) | ALDH1A1RAB9AMAPTHPGDLMNA | |
| SCHEMBL20344487 | 0.67 | ADH1B (0.52) | ALDH1A1RAB9AMAPTHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |