Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.32 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22048466 | 0.77 | MEN1 (0.33) | ALDH1A1HPGDMAPTNPSR1MAOB | |
| SCHEMBL19980436 | 0.72 | HTR2C (0.41) | ALDH1A1HPGDHTTCYP19A1MAPT | |
| SCHEMBL23337299 | 0.72 | CYP19A1 (0.35) | ALDH1A1HTTCYP19A1MAPTPOLB | |
| SCHEMBL24034861 | 0.70 | LMNA (0.38) | HPGDLMNASMN1; SMN2TSHRMAPK1 | |
| SCHEMBL22048701 | 0.70 | KMT2A (0.47) | ALDH1A1HPGDSMN1; SMN2TSHRMAPK1 | |
| SCHEMBL19980139 | 0.70 | CSNK2A1 (0.40) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 | |
| SCHEMBL19655565 | 0.68 | ALDH1A1 (0.42) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 | |
| SCHEMBL21156315 | 0.68 | ALDH1A1 (0.35) | ALDH1A1HPGDHTTCYP19A1MAPT | |
| SCHEMBL13475555 | 0.67 | HTT (0.51) | ALDH1A1MCOLN3HPGDLMNAHTT | |
| SCHEMBL19980506 | 0.67 | LRRK2 (0.36) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |