Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344598 | 0.80 | HPGD (0.38) | ALDH1A1HPGDHSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL23189282 | 0.80 | HPGD (0.38) | ALDH1A1HPGDHSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL23337299 | 0.68 | CYP19A1 (0.35) | ALDH1A1KDM4EHTTMAPT | |
| SCHEMBL19980263 | 0.67 | ALDH1A1 (0.34) | ALDH1A1HPGDSMN1; SMN2HTTMAPT | |
| SCHEMBL20344526 | 0.67 | LMNA (0.42) | LRRK2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL24034861 | 0.66 | LMNA (0.38) | HPGDSMN1; SMN2LMNAMAPK1TSHR | |
| SCHEMBL20344551 | 0.66 | LCLAT1 (0.45) | ALDH1A1HPGDHSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL19980436 | 0.66 | HTR2C (0.41) | ALDH1A1HPGDHSD17B10KDM4EHTT | |
| SCHEMBL22048695 | 0.65 | KDM4E (0.40) | LRRK2ALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL23997032 | 0.64 | LRRK2 (0.48) | LRRK2ALDH1A1HPGDHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3375780-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-06-03 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-2956452-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2018-03-21 | — | — | EP | disclosed |