Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19980463 | 0.87 | MAOA (0.33) | PDK2 | |
| SCHEMBL12337351 | 0.82 | CRHBP (0.39) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL23430646 | 0.80 | KEAP1 (0.63) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL30343464 | 0.80 | CYP1A2 (0.47) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL19980414 | 0.80 | CYP1A2 (0.47) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL2723227 | 0.78 | KDM4E (0.42) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL9613694 | 0.78 | KEAP1 (0.58) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL19974226 | 0.76 | ESR1 (0.34) | CRHBPCRHR2KEAP1NFE2L2KDM4E | |
| SCHEMBL29516015 | 0.74 | ALDH1A1 (0.54) | CRHBPCRHR2KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL19974426 | 0.74 | ALDH1A1 (0.54) | CRHBPCRHR2KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| WO-2018050584-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |