Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | LCLAT1 | Q6UWP7 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20344598 | 0.91 | HPGD (0.38) | HPGDALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL20344551 | 0.81 | LCLAT1 (0.45) | HPGDALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL19980507 | 0.81 | ACHE (0.53) | SMN1; SMN2KDM4ERAB9AHSD17B10NPC1 | |
| SCHEMBL21155980 | 0.80 | NOTUM (0.45) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19980506 | 0.80 | LRRK2 (0.36) | HPGDALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL19980257 | 0.79 | HTR1D (0.41) | HPGDALDH1A1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL20344681 | 0.74 | CYP1A2 (0.45) | HPGDALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL22710190 | 0.74 | ROCK2 (0.48) | — | |
| SCHEMBL22048701 | 0.72 | KMT2A (0.47) | HPGDALDH1A1SMN1; SMN2KDM4ERAB9A | |
| SCHEMBL19980139 | 0.72 | CSNK2A1 (0.40) | HPGDALDH1A1SMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2021-04-07 | — | — | EP | disclosed |