Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655021 | 0.90 | ALDH1A1 (0.49) | ALDH1A1TSHRMCHR1ERN1HPGDS | |
| SCHEMBL15871541 | 0.89 | MCHR1 (0.48) | ALDH1A1TSHRMCHR1ERN1HPGDS | |
| SCHEMBL19981535 | 0.89 | DRD2 (0.55) | ALDH1A1TSHRMCHR1MEN1KMT2A | |
| SCHEMBL23347871 | 0.88 | MCHR1 (0.46) | ALDH1A1TSHRMCHR1ERN1HPGDS | |
| SCHEMBL20019688 | 0.86 | TAS1R3 (0.49) | ALDH1A1TSHRMCHR1HPGDSKMT2A | |
| SCHEMBL16222341 | 0.86 | ALDH1A1 (0.56) | ALDH1A1TSHRMCHR1ERN1HPGDS | |
| SCHEMBL16219434 | 0.84 | ALDH1A1 (0.54) | ALDH1A1TSHRMCHR1ERN1HPGDS | |
| SCHEMBL19464789 | 0.83 | TLR9 (0.58) | ALDH1A1TSHRMCHR1ERN1MAPT | |
| SCHEMBL24368189 | 0.83 | MCHR1 (0.59) | ALDH1A1TSHRMCHR1HPGDSMEN1 | |
| SCHEMBL19981430 | 0.82 | USP2 (0.45) | ALDH1A1TSHRMCHR1ERN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |