Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981405 | 0.89 | ALDH1A1 (0.52) | DRD4ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL15443854 | 0.88 | DRD2 (0.55) | DRD2DRD4USP30ALDH1A1NPC1 | |
| SCHEMBL15871568 | 0.87 | DRD2 (0.54) | DRD2DRD4USP30ALDH1A1NPC1 | |
| SCHEMBL20019688 | 0.86 | TAS1R3 (0.49) | DRD2DRD4USP30ALDH1A1NPC1 | |
| SCHEMBL19981430 | 0.84 | USP2 (0.45) | ALDH1A1RAB9ATSHRMCHR1HTR7 | |
| SCHEMBL20019694 | 0.83 | ABL1 (0.49) | DRD2DRD4USP30RAB9AKMT2A | |
| SCHEMBL16209894 | 0.82 | DRD2 (0.61) | DRD2DRD4USP30ALDH1A1NPC1 | |
| SCHEMBL14980322 | 0.82 | DRD2 (0.63) | DRD2DRD4USP30ALDH1A1NPC1 | |
| SCHEMBL14655021 | 0.79 | ALDH1A1 (0.49) | DRD4ALDH1A1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL28900449 | 0.79 | DRD2 (0.60) | DRD2DRD4USP30NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |
| EP-2788488-B1 | METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-03-21 | — | — | EP | disclosed |