Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981716 | 0.81 | UGT2B17 (0.38) | PNMTADRA1DADRA1AADRA1BMEN1 | |
| SCHEMBL12024897 | 0.77 | — | — | |
| SCHEMBL13303498 | 0.74 | UGT2B17 (0.47) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL17970208 | 0.73 | UGT2B17 (0.42) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL2921714 | 0.72 | PNMT (0.31) | PNMT | |
| SCHEMBL10513171 | 0.67 | PNMT (0.31) | PNMT | |
| SCHEMBL19981574 | 0.67 | PNMT (0.44) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL2845448 | 0.66 | KDM4E (0.38) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL19643822 | 0.66 | SIRT1 (0.41) | MEN1TSHRCYP2C19RAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL18424960 | 0.66 | MEN1 (0.37) | PNMTMEN1TSHRCYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |