Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B17 | O75795 | 2/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.32 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13303498 | 0.89 | UGT2B17 (0.47) | UGT2B17PNMTMEN1TSHRCYP2C19 | |
| SCHEMBL17970208 | 0.87 | UGT2B17 (0.42) | UGT2B17PNMTMEN1TSHRCYP2C19 | |
| SCHEMBL19981482 | 0.81 | PNMT (0.33) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL19981719 | 0.76 | MAPK1 (0.32) | UGT2B17 | |
| SCHEMBL12024884 | 0.76 | UGT2B17 (0.32) | UGT2B17 | |
| SCHEMBL2836592 | 0.75 | GAA (0.32) | MEN1RAB9AKMT2A | |
| SCHEMBL2834972 | 0.72 | PNMT (0.40) | PNMTMEN1TSHRCYP2C19RAB9A | |
| SCHEMBL2835011 | 0.71 | NPC1 (0.36) | RAB9A | |
| Hydrochloric Acid SCHEMBL10512635 | 0.69 | NPC1 (0.35) | RAB9A | |
| SCHEMBL19981574 | 0.69 | PNMT (0.44) | PNMTMEN1TSHRCYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |