Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981932 | 0.76 | CLK1 (0.38) | KDM4EMAPT | |
| SCHEMBL19981750 | 0.76 | BTK (0.37) | KDM4EMAPT | |
| SCHEMBL12025148 | 0.76 | BTK (0.43) | KDM4E | |
| SCHEMBL19981565 | 0.76 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL19981966 | 0.75 | BTK (0.37) | KDM4EMAPT | |
| SCHEMBL19981813 | 0.75 | BTK (0.36) | KDM4E | |
| SCHEMBL19981978 | 0.74 | BTK (0.32) | KDM4E | |
| SCHEMBL19981793 | 0.74 | CLK1 (0.42) | MAPT | |
| SCHEMBL19981725 | 0.69 | BTK (0.45) | — | |
| SCHEMBL26847445 | 0.59 | SMN1; SMN2 (0.56) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |