Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.32 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981969 | 0.94 | HDAC3 (0.38) | BTKFGRSRCTECBMX | |
| SCHEMBL19981966 | 0.93 | BTK (0.37) | BTKFGRSRCTECBMX | |
| SCHEMBL19981932 | 0.89 | CLK1 (0.38) | BTKFGRSRCTECBMX | |
| SCHEMBL19981813 | 0.88 | BTK (0.36) | BTKFGRSRCTECBMX | |
| SCHEMBL19981793 | 0.87 | CLK1 (0.42) | BTKFGRSRCTECBMX | |
| SCHEMBL19981562 | 0.84 | SLC9A1 (0.36) | BTKFGRSRCTECBMX | |
| SCHEMBL19981978 | 0.81 | BTK (0.32) | BTKFGRSRCTECBMX | |
| SCHEMBL19981725 | 0.81 | BTK (0.45) | BTKFGRSRCTECBMX | |
| SCHEMBL12025148 | 0.80 | BTK (0.43) | BTKFGRSRCTECBMX | |
| SCHEMBL19981565 | 0.78 | ALDH1A1 (0.38) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |