Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 18/20 | 0.42 |
| ▸ | CLK2 | P49760 | 6/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981932 | 0.91 | CLK1 (0.38) | CLK1DYRK1AFGRSRCTEC | |
| SCHEMBL19981813 | 0.90 | BTK (0.36) | CLK1FGRSRCTECBMX | |
| SCHEMBL19981750 | 0.87 | BTK (0.37) | CLK1FGRSRCTECBMX | |
| SCHEMBL19981969 | 0.87 | HDAC3 (0.38) | FGRSRCTECBMXBTK | |
| SCHEMBL19981966 | 0.86 | BTK (0.37) | FGRSRCTECBMXBTK | |
| SCHEMBL19981562 | 0.81 | SLC9A1 (0.36) | FGRSRCTECBMXBTK | |
| SCHEMBL19981978 | 0.79 | BTK (0.32) | FGRSRCTECBMXBTK | |
| SCHEMBL19981725 | 0.79 | BTK (0.45) | FGRSRCTECBMXBTK | |
| SCHEMBL12025148 | 0.78 | BTK (0.43) | FGRSRCTECBMXBTK | |
| SCHEMBL19981565 | 0.76 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |