Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997435 | 0.86 | PROKR1 (0.40) | PROKR1GFERTACR3SLC6A3KCNH2 | |
| SCHEMBL10253494 | 0.86 | NOTUM (0.44) | AKT1 | |
| SCHEMBL1993910 | 0.83 | KCNH2 (0.36) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| Trifluoroacetic Acid SCHEMBL1689684 | 0.82 | HDAC1 (0.42) | AKT1 | |
| SCHEMBL19444822 | 0.81 | GABRD (0.39) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL1689732 | 0.81 | NOTUM (0.51) | PROKR1TACR3AKT1 | |
| Hydrochloric Acid SCHEMBL2351254 | 0.81 | AKT1 (0.42) | PROKR1AKT1ALDH1A1CYP3A4HPGD | |
| SCHEMBL14675951 | 0.78 | PDE4B (0.36) | PROKR1AKT1 | |
| SCHEMBL7492026 | 0.70 | SIGMAR1 (0.54) | PROKR1GFERHPGDRIPK1 | |
| SCHEMBL6002415 | 0.70 | AVPR1A (0.42) | GABRDGABRA1GABRB1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960401-B2 | Spiropiperidine derivatives for controlling pests | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-14 | — | — | US | disclosed |
| EP-1694677-B1 | SPIROPIPERIDINE DERIVATIVES FOR CONTROLLING PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | SYNGENTA CROP PROTECTION, INC. | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135408-A1 | Spiropiperidine derivatives for controlling pests | CHRM1, CHRM2, RER1 | GABRD 4696/4885GABRA1 4478/4885GABRB1 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.