Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981920 | 0.76 | BTK (0.39) | EP300SYK | |
| SCHEMBL13363457 | 0.73 | BTK (0.37) | EP300 | |
| SCHEMBL24932139 | 0.62 | EP300 (0.45) | EP300SYKHDAC4 | |
| SCHEMBL21285960 | 0.59 | EP300 (0.54) | EP300 | |
| SCHEMBL29039129 | 0.57 | EP300 (0.41) | EP300SYKHDAC4 | |
| SCHEMBL13408175 | 0.55 | DEGS1 (0.51) | EP300 | |
| SCHEMBL13359259 | 0.55 | PPARG (0.42) | — | |
| SCHEMBL13408173 | 0.55 | DEGS1 (0.43) | — | |
| SCHEMBL7982049 | 0.54 | ALDH1A1 (0.39) | HDAC4 | |
| SCHEMBL15562919 | 0.54 | ALDH1A1 (0.39) | HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365970-B1 | PYRIDAZINONES AND THEIR USE AS BTK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2018-03-21 | — | — | EP | disclosed |