Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 2/20 | 0.51 |
| ▸ | KDM1A | O60341 | 7/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19974607 | 0.89 | YAP1 (0.54) | YAP1KDM1APOLBUSP30SIGMAR1 | |
| SCHEMBL19982162 | 0.83 | POLB (0.66) | YAP1POLBGRIN2BCHRNB2CHRNB4 | |
| SCHEMBL30117603 | 0.81 | YAP1 (0.57) | YAP1MAPTMAPK1 | |
| SCHEMBL4423185 | 0.80 | NPC1 (0.64) | POLB | |
| SCHEMBL19982103 | 0.80 | YAP1 (0.57) | YAP1KDM1A | |
| SCHEMBL19049602 | 0.77 | FKBP1A (0.67) | MAPK1 | |
| SCHEMBL19974551 | 0.76 | YAP1 (0.69) | YAP1POLB | |
| SCHEMBL20988916 | 0.75 | KMT2A (0.48) | YAP1KDM1APOLBKDM4EMAPT | |
| SCHEMBL19982110 | 0.74 | YAP1 (0.81) | YAP1 | |
| SCHEMBL19982111 | 0.74 | YAP1 (0.81) | YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |