Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 4/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982148 | 0.89 | YAP1 (0.51) | YAP1POLBGRIN2BCHRNB2CHRNB4 | |
| SCHEMBL24043594 | 0.84 | POLB (0.69) | YAP1POLBGRIN2BCHRNB2CHRNB4 | |
| SCHEMBL4423185 | 0.81 | NPC1 (0.64) | POLBNPC1TDP1NAAA | |
| SCHEMBL21359070 | 0.81 | YAP1 (0.60) | YAP1POLBGRIN2B | |
| SCHEMBL19982103 | 0.81 | YAP1 (0.57) | YAP1KDM1A | |
| SCHEMBL7298754 | 0.80 | ITGB3 (0.71) | SIGMAR1ITGB3ITGA2B | |
| SCHEMBL19974551 | 0.79 | YAP1 (0.69) | YAP1POLBITGB3ITGA2B | |
| SCHEMBL19049602 | 0.78 | FKBP1A (0.67) | NPC1TDP1NAAA | |
| SCHEMBL19974601 | 0.78 | YAP1 (0.54) | YAP1POLBGRIN2BNPC1TDP1 | |
| SCHEMBL19994624 | 0.76 | MAOB (0.60) | SIGMAR1KDM1AFAAHMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512839-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. Lee Moffitt Cancer Center And Research Institute, Inc. (US) | 2019-07-24 | — | — | EP | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |