Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 9/20 | 0.65 |
| ▸ | CTSK | P43235 | 7/20 | 0.65 |
| ▸ | CTSB | P07858 | 3/20 | 0.65 |
| ▸ | CTSL | P07711 | 1/20 | 0.65 |
| ▸ | BCL2 | P10415 | 1/20 | 0.65 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.57 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.57 |
| ▸ | PSMB5 | P28074 | 4/20 | 0.57 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.57 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.57 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.57 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | AKT1 | P31749 | 1/20 | 0.55 |
| ▸ | P4HB | P07237 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18435465 | 0.90 | CTSS (0.78) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL16254385 | 0.90 | CTSS (0.78) | CTSSCTSKCTSBCTSLAKT1 | |
| SCHEMBL12706406 | 0.89 | BCL2 (0.66) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL12706400 | 0.88 | BCL2 (0.65) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL7283532 | 0.87 | MMP9 (0.69) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL7283537 | 0.87 | MMP9 (0.69) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL23296282 | 0.87 | MMP9 (0.59) | CTSSCTSKCTSBCTSL | |
| SCHEMBL23296281 | 0.87 | MMP9 (0.59) | CTSSCTSKCTSBCTSL | |
| SCHEMBL11795364 | 0.87 | BCL2 (0.64) | CTSSCTSKCTSBCTSLBCL2 | |
| SCHEMBL11795371 | 0.87 | BCL2 (0.64) | CTSSCTSKCTSBCTSLBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234924-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234924-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2023-07-27 | — | — | US | disclosed |
| US-11530182-B2 | YAP1 inhibitors that target the interaction of YAP1 with Oct4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2022-12-20 | — | — | US | disclosed |
| US-20210130297-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2021-05-06 | — | — | US | disclosed |
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| WO-2018053446-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, IWS1, YES1 | CTSS 4757/4885CTSK 4751/4885CTSB 4840/4885 |
| US-20210130297-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | YAP1, YES1, MYC | CTSS 4691/4885CTSK 4716/4885CTSB 4817/4885 |
| US-20230234924-A1 | YAP1 INHIBITORS THAT TARGET THE INTERACTION OF YAP1 WITH OCT4 | YAP1, YES1, MYC | CTSS 4692/4885CTSK 4720/4885CTSB 4812/4885 |
| US-11530182-B2 | YAP1 inhibitors that target the interaction of YAP1 with Oct4 | YAP1, YES1, MYC | CTSS 4691/4885CTSK 4716/4885CTSB 4817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.