SCHEMBL1998230

SCHEMBL1998230

CCOC(=O)c1c(C(F)(F)F)cccc1C(F)(F)F

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
CA7 P43166 1/20 0.59
CA9 Q16790 1/20 0.59
CA14 Q9ULX7 1/20 0.59
KDM4E B2RXH2 2/20 0.53
ALDH1A1 P00352 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
TXNRD1 Q16881 1/20 0.49
HDAC4 P56524 2/20 0.49
HDAC6 Q9UBN7 2/20 0.49
HDAC3 O15379 1/20 0.49
HDAC1 Q13547 1/20 0.49
CYP1A2 P05177 1/20 0.49
TSHR P16473 1/20 0.48
POLB P06746 1/20 0.48
ELANE P08246 1/20 0.48
ALOX5 P09917 1/20 0.47
CACNA1C Q13936 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11694559 0.89 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL30294756 0.89 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL22853023 0.89 CA12 (0.51) CA12CA1CA2CA7CA9
SCHEMBL4740792 0.82 TXNRD1 (0.56) CA12CA1CA2CA7CA9
SCHEMBL1994129 0.81 TSHR (0.67) KDM4EALDH1A1L3MBTL1HDAC4HDAC6
SCHEMBL9573825 0.81 POLB (0.46) CA12CA1CA2CA7CA9
SCHEMBL7929905 0.80 ALDH1A1 (0.49) CA12CA1CA2CA7CA9
SCHEMBL1994212 0.79 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL7177043 0.79 TXNRD1 (0.47) CA12CA1CA2CA7CA9
SCHEMBL11696222 0.79 HSD17B10 (0.55) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
EP-0187462-B1 SUPPORTED OLEFIN POLYMERIZATION CATALYST AMOCO CORPORATION (US) 1990-04-25 EP claimed
EP-0187462-A2 Supported olefin polymerization catalyst AMOCO CORPORATION (US) 1986-07-16 EP claimed
US-4581342-A COMPLEX OF MAGNESIUM ALKYL COMPOUND WITH HINDERED AROMATIC ACID ESTER STANDARD OIL COMPANY (INDIANA) (US) 1986-04-08 US claimed
EP-4397674-A1 CASPASE-2 INHIBITOR COMPOUNDS Kintsugi Therapeutics S.L. (ES) 2024-07-10 EP disclosed
EP-4112631-A1 CASPASE-2 INHIBITOR COMPOUNDS Kintsugi Therapeutics S.L. (ES) 2023-01-04 EP disclosed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US disclosed
EP-2338935-B1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS CO LTD (JP) 2012-12-12 EP disclosed
US-20110172336-A1 FLUOROCOPOLYMER COMPOSITION AND ITS PRODUCTION PROCESS ASAHI GLASS COMPANY, LIMITED (JP) 2011-07-14 US disclosed
EP-2338935-A1 FLUORINE-CONTAINING COPOLYMER COMPOSITION AND PROCESS FOR PRODUCTION THEREOF ASAHI GLASS COMPANY, LIMITED (JP) 2011-06-29 EP disclosed
EP-0187462-B1 SUPPORTED OLEFIN POLYMERIZATION CATALYST AMOCO CORPORATION (US) 1990-04-25 EP disclosed
EP-0187462-A2 Supported olefin polymerization catalyst AMOCO CORPORATION (US) 1986-07-16 EP disclosed
US-4581342-A COMPLEX OF MAGNESIUM ALKYL COMPOUND WITH HINDERED AROMATIC ACID ESTER STANDARD OIL COMPANY (INDIANA) (US) 1986-04-08 US disclosed