SCHEMBL7929905

SCHEMBL7929905

CCOC(=O)c1c(C(F)(F)F)ccc(F)c1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HDAC4 P56524 2/20 0.48
HDAC6 Q9UBN7 2/20 0.48
HDAC3 O15379 1/20 0.48
HDAC1 Q13547 1/20 0.48
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA7 P43166 1/20 0.45
CA9 Q16790 1/20 0.45
CA14 Q9ULX7 1/20 0.45
MAPK8 P45983 1/20 0.43
MAPK10 P53779 1/20 0.43
POLB P06746 1/20 0.42
TP53 P04637 1/20 0.42
HTT P42858 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
HPGD P15428 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8158046 0.86 ALDH1A1 (0.48) ALDH1A1L3MBTL1HDAC4HDAC6HDAC3
SCHEMBL8157649 0.85 ALDH1A1 (0.47) ALDH1A1L3MBTL1HDAC4HDAC6HDAC3
SCHEMBL31459345 0.84 ALDH1A1 (0.49) ALDH1A1L3MBTL1HDAC4HDAC6HDAC3
SCHEMBL7932574 0.83 NOTUM (0.49) CA12CA1CA2CA7CA9
SCHEMBL1997194 0.83 CA12 (0.53) ALDH1A1CA12CA1CA2CA7
SCHEMBL1998230 0.80 CA12 (0.59) ALDH1A1L3MBTL1HDAC4HDAC6HDAC3
SCHEMBL29037249 0.79 TSHR (0.52) ALDH1A1CA12CA1CA2CA7
SCHEMBL12945976 0.78 TP53 (0.45) ALDH1A1CA12CA1CA2CA7
SCHEMBL8107311 0.78 ALDH1A1 (0.47) ALDH1A1CA12CA1CA2CA7
SCHEMBL7929890 0.77 HDAC4 (0.47) ALDH1A1L3MBTL1HDAC4HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0847977-B1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2001-08-29 EP disclosed
US-6054605-A CHEMICAL INTERMEDIATE FOR DRUGS, PESTICIDES NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
EP-0847977-A1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1998-06-17 EP disclosed