Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701474 | 0.84 | IDO1 (0.43) | IDO1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3207675 | 0.84 | IDO1 (0.43) | IDO1OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL13490301 | 0.74 | IDO1 (0.43) | IDO1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1922245 | 0.73 | IDO1 (0.42) | IDO1ADRA2BADRA2CADRA1A | |
| SCHEMBL2541173 | 0.73 | IDO1 (0.42) | IDO1ADRA2BADRA2CADRA1A | |
| SCHEMBL30578367 | 0.73 | IDO1 (0.42) | IDO1ADRA2BADRA2CADRA1A | |
| SCHEMBL413037 | 0.70 | ADRA2A (0.49) | IDO1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL12437186 | 0.68 | ACHE (0.48) | IDO1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1508536 | 0.68 | OPRL1 (0.51) | IDO1ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL1150672 | 0.68 | ACHE (0.48) | IDO1ADRA2AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309739-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2012-11-13 | — | — | US | disclosed |
| US-8309739-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2012-11-13 | — | — | US | disclosed |
| US-8309739-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2012-11-13 | — | — | US | disclosed |
| US-20110218341-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110218341-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-20110218341-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-09-08 | — | — | US | disclosed |
| US-7960310-B2 | Method of combating and controlling insects | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-14 | — | — | US | disclosed |
| US-7960310-B2 | Method of combating and controlling insects | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-14 | — | — | US | disclosed |
| US-7960310-B2 | Method of combating and controlling insects | SYNGENTA PARTICIPATIONS AG (CH) | 2011-06-14 | — | — | US | disclosed |
| EP-1919886-B1 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-10-06 | — | — | EP | disclosed |
| US-20100048699-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048699-A1 | CHEMICAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| EP-2043444-A1 | CHEMICAL COMPOUNDS | Syngenta Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| US-20080300285-A1 | Chemical Compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-20080300285-A1 | Chemical Compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-20080300285-A1 | Chemical Compounds | SYNGENTA CROP PROTECTION, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| EP-1919886-A2 | CHEMICAL COMPOUNDS | Syngeta Participations AG (CH) | 2008-05-14 | — | — | EP | disclosed |
| WO-2008009881-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED. (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009881-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED. (GB) | 2008-01-24 | — | — | WO | disclosed |
| WO-2007020377-A2 | CHEMICAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2007-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300285-A1 | Chemical Compounds | CHRM5, OR10J3, CHRM3 | IDO1 1415/4885ADRA2A 1863/4885ADRA2B 1522/4885 |
| US-20100048699-A1 | CHEMICAL COMPOUNDS | ACHE, TYR, SGMS1 | IDO1 711/4885ADRA2A 2647/4885ADRA2B 2695/4885 |
| US-20110218341-A1 | CHEMICAL COMPOUNDS | OR10J3, NR0B1, NR0B2 | IDO1 1301/4885ADRA2A 2245/4885ADRA2B 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.