SCHEMBL19982693

SCHEMBL19982693

O=NC(=O)c1cccc(-c2ncon2)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.48
ADORA2A P29274 5/20 0.41
ADORA1 P30542 5/20 0.41
LRRK2 Q5S007 1/20 0.37
HDAC6 Q9UBN7 2/20 0.36
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
KEAP1 Q14145 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
KMO O15229 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL941077 0.83 KMO (0.53) KAT6AADORA2AADORA1HDAC6KEAP1
SCHEMBL29045125 0.78 NPC1 (0.52) KAT6ANPC1RAB9A
SCHEMBL17984217 0.72 GP6 (0.44) KAT6AADORA2AADORA1LRRK2NPC1
SCHEMBL14027556 0.71 FGFR3 (0.48) KAT6AADORA2AADORA1MAOA
SCHEMBL4325008 0.70 NOTUM (0.46) KAT6ALRRK2PPARA
SCHEMBL13466167 0.70 MEN1 (0.50) KAT6ANPC1RAB9APPARAMAOA
SCHEMBL29930074 0.70 MEN1 (0.50) KAT6ANPC1RAB9APPARAMAOA
SCHEMBL31010202 0.70 RAB9A (0.49) NPC1RAB9AL3MBTL1HCRTR1HCRTR2
SCHEMBL12457 0.70 RAB9A (0.49) NPC1RAB9AL3MBTL1HCRTR1HCRTR2
SCHEMBL30212930 0.70 MAP4K4 (0.50) KAT6ALRRK2NPC1RAB9AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018050706-A1 METHOD OF TREATMENT OF SHWACHMAN-DIAMOND SYNDROME CIPOLLI MARCO (IT) 2018-03-22 WO disclosed