Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.66 |
| ▸ | CTSL | P07711 | 1/20 | 0.66 |
| ▸ | CTSH | P09668 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19972799 | 0.99 | CTSK (0.67) | CTSKCTSLCTSH | |
| SCHEMBL19972801 | 0.99 | CTSK (0.67) | CTSKCTSLCTSH | |
| SCHEMBL25658980 | 0.90 | CTSK (0.55) | CTSKCTSL | |
| SCHEMBL19972784 | 0.86 | CTSK (0.62) | CTSKCTSLCTSH | |
| SCHEMBL19972781 | 0.86 | CTSK (0.62) | CTSKCTSLCTSH | |
| SCHEMBL19983060 | 0.83 | CTSL (0.49) | CTSKCTSL | |
| SCHEMBL19983189 | 0.80 | CTSK (1.00) | CTSKCTSL | |
| SCHEMBL19983012 | 0.80 | CTSK (1.00) | CTSKCTSL | |
| SCHEMBL30716858 | 0.80 | CTSK (1.00) | CTSKCTSL | |
| SCHEMBL25658928 | 0.77 | CTSK (0.51) | CTSKCTSLCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11325884-B2 | Ketone inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20210053908-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2021-02-25 | — | — | US | disclosed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053908-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | CTSK 379/4885CTSL 264/4885CTSH 874/4885 |
| US-11325884-B2 | Ketone inhibitors of lysine gingipain | PHYKPL, ENPEP, PREP | CTSK 379/4885CTSL 264/4885CTSH 874/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.