Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL22325631 | 0.90 | TGFBR1 (0.36) | TDP1TSHRTGFBR1FFAR3HDAC3 | |
| Methacrylic Acid SCHEMBL999438 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HSD17B10 | |
| Methacrylic Acid SCHEMBL3124718 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HDAC3 | |
| Methacrylic Acid SCHEMBL29038212 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HDAC3 | |
| Methacrylic Acid SCHEMBL570136 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HDAC3 | |
| Methacrylic Acid SCHEMBL6862647 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HSD17B10 | |
| Methacrylic Acid SCHEMBL9632125 | 0.89 | TDP1 (0.42) | TDP1TSHRTGFBR1FFAR3HDAC3 | |
| Methacrylic Acid SCHEMBL224237 | 0.86 | TDP1 (0.36) | TDP1TSHRTGFBR1FFAR3ALDH1A1 | |
| Methacrylic Acid SCHEMBL22493124 | 0.86 | TDP1 (0.40) | TDP1TSHRTGFBR1FFAR3HSD17B10 | |
| Methacrylic Acid SCHEMBL11177420 | 0.86 | TDP1 (0.40) | TDP1TSHRTGFBR1FFAR3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555747-B1 | A COMBINATION OF CROSSLINKED CATIONIC POLYMER AND AMPHOLYTIC POLYMER FOR PERSONAL AND HOUSEHOLD APPLICATIONS | LUBRIZOL ADVANCED MAT INC (US) | 2017-02-22 | — | — | EP | claimed |
| US-7964545-B2 | Skin cleansing composition | KAO CORPORATION (JP) | 2011-06-21 | — | — | US | disclosed |
| US-20090286707-A1 | SKIN CLEANSING COMPOSITION | KAO CORPORATION (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286707-A1 | SKIN CLEANSING COMPOSITION | DEGS1, SGMS1, SPTAN1 | TDP1 1826/4885TSHR 4875/4885TGFBR1 3027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.