Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL27040265 | 0.97 | TDP1 (0.35) | TDP1TGFBR1ALDH1A1FFAR3THRB | |
| Methacrylic Acid SCHEMBL154987 | 0.97 | TDP1 (0.35) | TDP1TGFBR1ALDH1A1FFAR3THRB | |
| Methacrylic Acid SCHEMBL31257129 | 0.97 | TDP1 (0.35) | TDP1TGFBR1ALDH1A1FFAR3THRB | |
| Methacrylic Acid SCHEMBL28838399 | 0.93 | TGFBR1 (0.36) | TDP1TGFBR1ALDH1A1 | |
| Methacrylic Acid SCHEMBL1998337 | 0.86 | TDP1 (0.35) | TDP1TGFBR1ALDH1A1FFAR3THRB | |
| Methacrylic Acid SCHEMBL1368368 | 0.85 | PTGS1 (0.33) | TDP1TGFBR1TSHR | |
| Methacrylic Acid SCHEMBL999438 | 0.85 | TDP1 (0.42) | TDP1TGFBR1ALDH1A1FFAR3LCK | |
| Methacrylic Acid SCHEMBL6862647 | 0.85 | TDP1 (0.42) | TDP1TGFBR1ALDH1A1FFAR3LCK | |
| Methacrylic Acid SCHEMBL27384167 | 0.84 | PTGS1 (0.32) | TGFBR1TSHR | |
| Methacrylic Acid SCHEMBL28305261 | 0.84 | PTGS1 (0.32) | TGFBR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118388715-A | Aqueous thickening emulsion, aluminum foil primer coating slurry and preparation method and application thereof | 宣城研一新能源科技有限公司 | 2024-07-26 | — | — | CN | claimed |
| CN-117801795-A | Cement paste plugging material for resisting underground fluid dilution, and preparation method and application thereof | 中国石油天然气集团有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-117645798-A | Liquefied reaction type petroleum asphalt with long-term normal-temperature storage stability | 河南金欧特实业集团股份有限公司 | 2024-03-05 | — | — | CN | claimed |
| CN-114075315-B | Environment-friendly fluorine-containing high-molecular surfactant and preparation method thereof | 南开大学 | 2024-02-27 | — | — | CN | claimed |
| WO-2024016587-A1 | WATER-BASED BINDER, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳市研一新材料有限责任公司 | 2024-01-25 | — | — | WO | claimed |
| CN-117000059-A | Blending and co-deposition modified dual-function separation membrane and preparation method thereof | 山东建筑大学 | 2023-11-07 | — | — | CN | claimed |
| CN-115073627-B | Porous organic polymer carrier metallocene catalyst system and preparation method and application thereof | 中国石油天然气股份有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-115050922-B | Water-based adhesive and preparation method and application thereof | 深圳市研一新材料有限责任公司 | 2023-06-30 | — | — | CN | claimed |
| CN-114874699-B | Bionic modified organic silicon marine antifouling paint and preparation method thereof | 常熟理工学院 | 2023-05-02 | — | — | CN | claimed |
| CN-112592304-B | Polymerizable photoacid generator containing double onium salt structure, preparation method and photoresist | 宁波南大光电材料有限公司 | 2023-01-17 | — | — | CN | claimed |
| CN-114075315-A | Environment-friendly fluorine-containing polymer surfactant and preparation method thereof | 南开大学 | 2022-02-22 | — | — | CN | claimed |
| CN-109796561-B | Aromatic ring polycarboxylic acid water reducing agent mother liquor and preparation method and application thereof | 科之杰新材料集团(贵州)有限公司 | 2021-06-15 | — | — | CN | claimed |
| CN-112592304-A | Polymerizable photoacid generator containing double-onium salt structure, preparation method and photoresist | 宁波南大光电材料有限公司 | 2021-04-02 | — | — | CN | claimed |
| CN-111423545-A | High-water-reducing low-loss water reducing agent containing polyether phosphate monomer | 厦门路桥翔通建材科技有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-105482033-B | A kind of polymer microballoon and its preparation method and application | 中国石油化工股份有限公司 | 2017-12-19 | — | — | CN | claimed |
| CN-105482035-B | A kind of polyacrylamide and its preparation method and application | 中国石油化工股份有限公司 | 2017-08-25 | — | — | CN | claimed |
| CN-105482033-A | Polymer microsphere and preparation method and application thereof | CHINA PETROLEUM & CHEM CORP | 2016-04-13 | — | — | CN | claimed |
| CN-105482035-A | Polyacrylamide, and preparation method and application thereof | CHINA PETROLEUM & CHEM CORP | 2016-04-13 | — | — | CN | claimed |
| US-20070166269-A1 | Cosmetic composition containing a statistical polymer with a linear chain of ethylenic nature | L'OREAL (FR) | 2007-07-19 | — | — | US | claimed |
| US-20070092473-A1 | Cosmetic composition containing a statistical polymer with a linear main chain of ethylenic nature | L'OREAL (FR) | 2007-04-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070166269-A1 | Cosmetic composition containing a statistical polymer with a linear chain of ethylenic nature | POLH, LAGE3, ELOVL6 | TDP1 1433/4885TGFBR1 4062/4885ALDH1A1 3735/4885 |
| US-20070092473-A1 | Cosmetic composition containing a statistical polymer with a linear main chain of ethylenic nature | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, TELO2, METTL14 | TDP1 1444/4885TGFBR1 3597/4885ALDH1A1 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.