Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983903 | 0.83 | CYP2D6 (0.39) | GPR84CHRNB2CHRNA7CHRNA4CYP1A2 | |
| SCHEMBL19984110 | 0.82 | GPR84 (0.44) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19983728 | 0.81 | CHRNB2 (0.39) | GPR84CHRNB2CHRNA7CHRNA4PTK6 | |
| SCHEMBL19983851 | 0.78 | CHRNB2 (0.47) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19983983 | 0.78 | GPR84 (0.44) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19983731 | 0.78 | GPR84 (0.37) | GPR84CHRNB2CHRNA7CHRNA4P2RX3 | |
| SCHEMBL19983828 | 0.77 | LMNA (0.38) | GPR84CHRNB2CHRNA7CHRNA4NPC1 | |
| SCHEMBL19983765 | 0.77 | GPR84 (0.43) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19983887 | 0.77 | GPR84 (0.43) | GPR84CHRNB2CHRNA7CHRNA4HTR2A | |
| SCHEMBL19984142 | 0.76 | BACE1 (0.39) | GPR84P2RX3WEE1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |