Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19983912 | 0.88 | NR4A2 (0.50) | NR4A2CYP19A1CYP11B1CYP11B2ABCB1 | |
| SCHEMBL19983914 | 0.81 | FYN (0.37) | NR4A2PIK3CAPIK3CGCYP19A1CYP11B1 | |
| SCHEMBL16619065 | 0.79 | NR4A2 (0.49) | NR4A2PIK3CAPIK3CGRCE1CYP19A1 | |
| SCHEMBL19983968 | 0.75 | NR4A2 (0.38) | NR4A2ERN1 | |
| SCHEMBL19971444 | 0.70 | MEN1 (0.41) | NR4A2PIK3CAPIK3CGCYP19A1JAK2 | |
| SCHEMBL19983804 | 0.69 | EPHX2 (0.37) | — | |
| SCHEMBL16618580 | 0.69 | NR4A2 (0.50) | NR4A2CYP19A1CYP11B1CYP11B2SLC2A1 | |
| SCHEMBL7224515 | 0.67 | MKNK1 (0.55) | PIK3CAPIK3CGRCE1HSD17B1HSD17B2 | |
| SCHEMBL16618555 | 0.66 | KMT2A (0.52) | NR4A2PIK3CGCYP11B1CYP11B2GABRA1 | |
| SCHEMBL19984210 | 0.66 | PRMT6 (0.40) | NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | disclosed |